Laboratory of Molecular Metabolism

Research Focus

Obesity is closely linked to a number of metabolic diseases, such as diabetes, hypertension, cardiovascular disease, and many types of cancer. Interestingly, some fat cell types drive up these associated risks, while still others appear to be protective. How is this possible?

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Our Team

Established in 2015, the Laboratory of Molecular Metabolism is led by physician-scientist Paul Cohen. We are comprised of post-doctoral fellows, PhD students, MD-PhD students, medical students, and research assistants.

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Find Us

We are located in the Collaborative Research Center at The Rockefeller University. Our lab sits on the first floor of the Flexner Building. Rockefeller neighbors Weill Cornell Medical College and Memorial Sloan Kettering Cancer Center.

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We are interested in a number of questions that may help explain why obesity increases the risks of deadly co-morbidities:

  • What are the molecular mechanism underlying the development and phenotype of fat cells?
  • What are the specific phenotypes regulated by distinct fat cells (white, brown, and beige)?
  • How does fat cell phenotype contribute to disease?
  • Can we develop approaches to modulate fat cell phenotype?

Our interdisciplinary team collaborates with a number of labs to investigate adipose biology at the molecular, cellular, and organismal level.